As of May 2016 [update] , the signaling cascade that mediates the HMB-induced reduction in muscle protein breakdown has not been identified in living humans, although it is well-established that it attenuates proteolysis in humans in vivo .   Unlike L -leucine , HMB attenuates muscle protein breakdown in an insulin -independent manner in humans. [note 7]  HMB is believed to reduce muscle protein breakdown in humans by inhibiting the 19S and 20S subunits of the ubiquitin–proteasome system in skeletal muscle and by inhibiting apoptosis of skeletal muscle nuclei via unidentified mechanisms.   
250 Grams Lemon Lime
1 Scoop ( grams)
Servings Per Container: 45
Amount Per Serving % Daily Value*
Proprietary Blend 4145mg*
(Arginine Alpha-Ketoglutarate, Creatine Monohydrate, Beta Alanine, Caffeine, 1,3-Dimethylamylamine (Geranium [Stem]), Schizandrol A)
* Daily Value not established
Citric Acid, Natural Lemon-Lime Flavor, Acesulfame-K, Sucralose, Vegetable Stearate, Silicon Dioxide, Chlorophyll (For Coloring).
This product is produced in a facility that processes milk and soy ingredients
Black Box Warning:
This Product Produces An Intense Sensation Of Drive, Focus, Energy, Motiviation & Awareness. In Addition, It Allows For Rapid Increases In Strength, Speed, Power & Endurance. Therefore, Extreme Caution Must Be Exercised & Should Not Be Used By Novice Athletes.
Use With Caution Under Strict Dosing Protocols.