Back, abdominal, or stomach pain an adverse change in vision, coughing, shortness of breath, troubled breathing, tightness in the chest, or wheezing, discharge from the eye, dizziness, eye or eyelid pain, swelling, discomfort, or irritation, increased blood pressure, increased frequency of urination or painful urination, itching of the eyelid, seeing flashes or sparks of light, seeing floating spots before the eyes, swelling of lining of the eyelid, tiny bumps on lining of the eyelid, blistering, peeling, or loosening of the skin, blood in the urine, blue lips, fingernails, or skin, chest pain or discomfort, chills, cough, diarrhoea, difficult or troubled breathing, fainting, headache or weakness, severe and sudden, irregular, fast or slow, or shallow breathing, itching, joint or muscle pain, light-headedness, mental depression, nausea or vomiting, pain, numbness, tingling, or burning feeling in the hands or feet, red, irritated eyes, red skin lesions, often with a purple center, shortness of breath, skin rash,, slow or irregular heartbeat, sore throat, sores, ulcers, or white spots in the mouth or on the lips, sweating, unusual tiredness or weakness, cold- or flu-like symptoms, crusting or scales on eyelid, dryness of the eyes, indigestion or an upset stomach, a sore throat, a stuffy or runny nose, tearing of the eye, a burning, crawling, itching, numbness, prickling, “pins and needles”, or tingling feelings, depression, a dry mouth and/ or a stuffy nose.
Very common (10% or more): Headache
Common (1% to 10%): Dizziness, insomnia, somnolence, tremor, paresthesia, ataxia, nervousness, aphasia
Uncommon (% to 1%): Seizure, bad taste, cerebrovascular accident, intracranial hemorrhage, transient ischemic attack, neuralgia, muscle spasm, dysphoria, gait abnormality, hypertonia, hypokinesia, neurodermatitis, numbness (localized), dysarthria, dysphasia, nystagmus, pacing
Rare (less than %): Extrapyramidal symptoms
Very rare (less than %): Neuroleptic malignant syndrome [ Ref ]
The following adverse reactions have been identified during post-approval use of BOTOX. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. These reactions include: abdominal pain; alopecia , including madarosis; anorexia ; brachial plexopathy; denervation /muscle atrophy ; diarrhea; hyperhidrosis; hypoacusis; hypoaesthesia; malaise ; paresthesia ; peripheral neuropathy ; radiculopathy ; erythema multiforme , dermatitis psoriasiform, and psoriasiform eruption; strabismus; tinnitus ; and visual disturbances.