The structure of cyclocreatine is fairly flat (planar), which aids in passive diffusion across membranes. It has been used with success in an animal study, where mice suffered from a SLC6A8 (creatine transporter at the blood brain barrier) deficiency, which is not responsive to standard creatine supplementation.  This study failed to report increases in creatine stores in the brain, but noted a reduction of mental retardation associated with increased cyclocreatine and phosphorylated cyclocreatine storages.  As demonstrated by this animal study and previous ones, cyclocreatine is bioactive after oral ingestion   and may merely be a creatine mimetic, able to phosphorylate ADP via the creatine kinase system. 
The most frequent symptom is the pain. However, this is not an early symptom. As joint cartilage has no nerve fibers, the pains signals periarticular structure are involved.
Joint pain is generally described as a deep, dull, continuous type of pain restrictioned to a joint and its immediate environment. It occurs on movement but not at rest.
Symptoms such as:
• Brief intial pain, normally occuring after intensive or abonormal stress on the joint,
• Pain when beginning a movement ("warm-up" pain)
• Fatigue pain
• Stress pain (pain during exercise)
• Constant pain
• Night pain
• Local muscle pain (tension in muscles and tendons)
• Restricted movement
• Swollen joints
• Grinding of joints
To activate protein synthesis and increase muscle recovery, take 1 serving of AMINOCORE during weight training or any athletic event. On non-training days, AMINOCORE can be taken anytime on an empty stomach. Due to the potent nature of this product, it is not recommended to exceed 2 servings daily. Pour 1 scoop of AMINOCORE into water and shake or stir well. Take during workouts, or anytime you want to decrease muscle breakdown and increase protein synthesis. Carefully read the instructions on the label and follow the directions before use.