The majority of side effects from topical steroids occur within the nose at the site of local application. These side effects commonly include nasal irritation and nose bleeds . Should these symptoms occur, a person should stop using the nasal steroid for a few days, and then re-start the medication using the appropriate technique . If bleeding and irritation continue to occur, the nasal steroid should not be used any longer. A person who continues to use a nasal steroid despite these local side effects is at risk for septal perforation .
A total of 1008 patients aged 12 years and older received NASONEX Nasal Spray 50 mcg 200 mcg/day (n=506) or placebo (n=502) for 15 days. Adverse events that occurred more frequently in patients treated with NASONEX Nasal Spray 50 mcg than in patients with the placebo included sinus headache (% in NASONEX Nasal Spray 50 mcg group vs. % in placebo) and epistaxis (1% in NASONEX Nasal Spray 50 mcg group vs. % in placebo) and the overall adverse event profile was similar to that observed in the other allergic rhinitis trials.
Mometasone furoate increased chromosomal aberrations in an in vitro Chinese hamster ovary-cell assay, but did not increase chromosomal aberrations in an in vitro Chinese hamster lung cell assay. Mometasone furoate was not mutagenic in the Ames test or mouse- lymphoma assay, and was not clastogenic in an in vivo mouse micronucleus assay and a rat bone marrow chromosomal aberration assay or a mouse male germ -cell chromosomal aberration assay. Mometasone furoate also did not induce unscheduled DNA synthesis in vivo in rat hepatocytes.