The causes and management of steroid-resistant idiopathic NS in children will be reviewed here. The etiology, clinical manifestations, diagnosis, and initial management of NS in children are discussed separately. In addition, the management of children with steroid-sensitive nephrotic syndrome (SSNS) is presented elsewhere. (See "Etiology, clinical manifestations, and diagnosis of nephrotic syndrome in children" and "Treatment of idiopathic nephrotic syndrome in children", section on 'Initial pharmacologic therapy' and "Treatment of idiopathic nephrotic syndrome in children", section on 'Steroid-sensitive nephrotic syndrome' .)
I bought 1 kit 240 IU in 2016, results were fantastic and on par with pharma that I've been able to get at times when finances are looking good. When I got down to my last 2 vials I switched to another brand that I had in the fridge from earlier in the year and needed almost 3x to approximate the results of the GODT240. I typically use between 2-4 IU per day depending on intensity of workouts, and take some days off as well, have been using HGH for approx 10 years and had my share of fantastic and not so fantastic products, and as well have seen great suppliers drop off the map. Am planning to buy a new kit this month of December as a Christmas gift to myself & a lean year of finances had my HGH supply dwindle to nil, so I wanted to have a look at the reviews & see that things were still great with this product and am happy to find GODT240 is still delivering the goods
Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.