Signs of steroid induced atrophy

Results of the review showed that steroid-induced psychosis has been reported among children with asthma , autoimmune diseases, and cancer ; the average age of these patients when they experienced the side effect was 12± years. Regarding the case, the authors reported on a 12-year-old patient with discoid-type lupus erythematosus who developed steroid-induced psychosis days after initiating treatment with prednisone. "Within days of treatment with 40mg prednisone daily, this patient began to drool, became mute, and was responding to internal stimuli," the authors write. After a Neurology consult ruled out lupus cerebritis, the patient was treated with haloperidol 5mg, however, the psychosis did not resolve until the steroid was discontinued.   Related Articles

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During conventional pharmacologic dose corticosteroid therapy, ACTH production is inhibited with subsequent suppression of cortisol production by the adrenal cortex. Recovery time for normal HPA activity is variable depending upon the dose and duration of treatment. During this time the patient is vulnerable to any stressful situation. Although it has been shown that there is considerably less adrenal suppression following a single morning dose of prednisolone (10 mg) as opposed to a quarter of that dose administered every six hours, there is evidence that some suppressive effect on adrenal activity may be carried over into the following day when pharmacologic doses are used. Further, it has been shown that a single dose of certain corticosteroids will produce adrenal cortical suppression for two or more days. Other corticoids, including methylprednisolone, hydrocortisone, prednisone, and prednisolone, are considered to be short acting (producing adrenal cortical suppression for 1¼ to 1½ days following a single dose) and thus are recommended for alternate day therapy.

“ Long-term psychiatric and medical consequences of anabolic-androgenic steroid abuse: a looming public health concern? ”
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Signs of steroid induced atrophy

signs of steroid induced atrophy

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