Steroid affect immune system

"For years I had been a "junkie"--addicted to prescription and over the counter drugs. used oral and topical anti-inflammatory corticosteroids for 9 years to suppress my eczema/psoriasis. The steroids' side effect nearly killed me and did nothing to cure my eczema. Why elimination or suppression of the symptom is NOT the same as elimination of the disease . The side effects caused me to swell-up like a balloon and triggered terrible mood swings from deep depression to nasty outburst our rages. Functioning of vital organs such as my liver, kidneys, lungs and spleen were nearly shut down and I thought I would die." Shirley

Cells of the zona fasciculata and zona reticularis lack aldosterone synthase (CYP11B2) that converts corticosterone to aldosterone, and thus these tissues produce only the weak mineralocorticoid corticosterone. However, both these zones do contain the CYP17A1 missing in zona glomerulosa and thus produce the major glucocorticoid, cortisol. Zona fasciculata and zona reticularis cells also contain CYP17A1, whose 17,20-lyase activity is responsible for producing the androgens, dehydroepiandrosterone (DHEA) and androstenedione. Thus, fasciculata and reticularis cells can make corticosteroids and the adrenal androgens, but not aldosterone.

• What the experts say: Though the FDA did not conclude definitively that the events reported were induced by the drugs, the agency in June 2009 requested that the manufacturers of these drugs include a precaution about neuropsychiatric events in their prescribing information and labeling. “[Right now] it is unclear is whether suicidal thoughts and actions are strictly a consequence of the drug, some underlying effect of asthma, or a result of the impact that asthma has on ones sense of self worth and quality of life,” Dr. Calhoun says.

FDA. “FDA approves Amjevita, a biosimilar to Humira.”
Kurd, . Journal of the American Academy of Dermatology , April 2008.
Medscape: "FDA OKs Biologic Guselkumab (Tremfya) for Plaque Psoriasis."
Arthritis Foundation: “Latest Treatments for Psoriatic Arthritis.”
National Cancer Institute: "Dictionary of Cancer Terms: Turmeric."
National Psoriasis Foundation: "Complementary approaches: natural elements;" "Over-the-counter (OTC) Topicals;" "Can Diet Heal Psoriasis?" and "Gluten-free Diet."
University of Maryland Medical Center: "Psoriasis -- Treatment."
University of Michigan Health System: "Psoriasis Topic Overview."
University of Maryland Medical Center: "Aloe."
University of Michigan Health System: "Psoriasis."

Steroid affect immune system

steroid affect immune system

FDA. “FDA approves Amjevita, a biosimilar to Humira.”
Kurd, . Journal of the American Academy of Dermatology , April 2008.
Medscape: "FDA OKs Biologic Guselkumab (Tremfya) for Plaque Psoriasis."
Arthritis Foundation: “Latest Treatments for Psoriatic Arthritis.”
National Cancer Institute: "Dictionary of Cancer Terms: Turmeric."
National Psoriasis Foundation: "Complementary approaches: natural elements;" "Over-the-counter (OTC) Topicals;" "Can Diet Heal Psoriasis?" and "Gluten-free Diet."
University of Maryland Medical Center: "Psoriasis -- Treatment."
University of Michigan Health System: "Psoriasis Topic Overview."
University of Maryland Medical Center: "Aloe."
University of Michigan Health System: "Psoriasis."

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